TITLE:
Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at different ages
AUTHORS:
Daniel Perez-Torres, Cruz Reyes-Vázquez, Mireya Velázquez-Paniagua, Bertha P rieto-Gómez
KEYWORDS:
Melatonin; Unitary Neuronal Activity; Hippocampus; Rat; Age
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.1,
February
17,
2014
ABSTRACT: Melatonin, the pineal
indole is characterized by being a compound that crosses all cell membranes
and which has been attributed to several mechanisms of action. Among these it
is the ability to reduce free radicals, thereby reducing the potential aging
and cell death. Studies in different age Wistar rats have shown that chronic
application of melatonin, in the hippocampus, reduces the concentration of
free radicals and keeps its architecture. This study showed that melatonin
increases the firing rate and favors the presence of bursting activity in
animals of different ages. It is suggested that melatonin conserved hippocampal
cells in good anatomical and physiological condition probably as a result of
the elimination of free radicals.