TITLE:
Bioabsorbable Barrier Membrane Combined with rhBMP-2 Improved Bone Formation in an Experimental Model of Compromised Healing But Was Not Superior to rhBMP-2 Alone
AUTHORS:
Henrik Eckardt, Knud Stenild Christensen, Martin Lind, Ebbe Stender Hansen, Ivan Hvid
KEYWORDS:
Bioabsorbable Barrier Membrane; Bone Morphogenetic Protein 2; Non Union; Pseudartrhrosis; Rabbit; Bone Blood Flow; Torsion to Failure
JOURNAL NAME:
Open Journal of Orthopedics,
Vol.4 No.2,
February
14,
2014
ABSTRACT: Objective: Bioabsorbable barrier membranes placed
over alveolar ridge bone defects are routinely used in dental surgery to
promote bone formation. Combining these osteoconductive membranes with
osteoinductive Bone Morphogenetic Proteins could prove useful in long bone
fracture treatment. The hypothesis was tested in a clinically relevant model of
compromised healing. Methods: Four groups of 8 rabbits underwent unilateral
mid-tibial osteotomy, excision of periosteum and endosteum, and plate fixation.
One group had rhBMP-2 deposited between the bone ends and Membrane wrapped
around the osteotomy, the second group had Membrane wrapped around the
osteotomy, the third group had rhBMP-2 placed between the bone ends, and the
fourth group received no additional treatment. Results: After 7 weeks, callus size and blood flow were significantly
higher in the Membrane+rhBMP-2 group than in the rhBMP-2 treated group, but
torsion to failure test showed no significant difference. Membrane treatment
and no treatment led to non-union. Conclusion: Absorbable barrier membrane
combined with rhBMP-2 enhances bone formation, but has no advantage to rhBMP-2
alone. Membrane alone wrapped around the osteotomy was unable to prevent
non-union formation.