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Petit, J.M., Benichou, M., Duvillard, L., Jooste, V., Bour, J.B., Minello, A., Verges, B., et al. (2003) Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis. The American Journal of Gastroenterology, 98, 1150-1154.

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• TITLE: Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

  AUTHORS: Engin Altintas, Zuhal Mert Altintas, Orhan Sezgin, Enver Ucbilek, Erdinc Nayir, Mehmet Emin Erdal, Ayse Polat, Gulhan Orekeci

  KEYWORDS: Fibrosis; Hepatitis C; Gene Polymorphism; Methylenetetrahydrofolate Reductase; Steatosis

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.4 No.2, February 14, 2014

  ABSTRACT: Aim & Background: The mechanism of steatosis in Hepatitis C virus infection is multifactorial; therefore, it is complex and unclear. The aim of this study was to investigate the effects of methylentetrahydrofolate reductase (MTHFR) gene polymorphisms on the course of chronic hepatitis C virus infection and the development of steatosis due to hepatitis C virus. Methods: This study included 109 patients with chronic hepatitis C virus infection. Necroinflammatory activity, degrees of fibrosis and steatosis and MTHFR gene polymorphisms were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to determine MTHFR C677T and A1298C polymorphisms. Results: Fibrosis was correlated with age (r = 0.336, p = 0.002), platelet (r = ?0.448, p was a relation between MTHFR C677T and the degree of fibrosis but not A1298C (p = 0.014, p = 0.187 respectively). Conclusion: We found that MTHFR C677T polymorphism contributed to the development of fibrosis in patients with chronic hepatitis C virus infection.