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Radi, M., Crespan, E., Botta, G., Falchi, F., Maga, G., Manetti, F., Corradi, V., Mancini, M., Santucci, M.A., Schenone, S. and Bott, M. (2008) Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorganic & Medicinal Chemistry Letters, 18, 1207-1211.

has been cited by the following article:

• TITLE: Synthesis and antimicrobial activity of Ibuprofen derivatives

  AUTHORS: Ibtihal Q. Abdulla

  KEYWORDS: Ibuprofen; Biological Active Compounds

  JOURNAL NAME: Natural Science, Vol.6 No.2, February 14, 2014

  ABSTRACT: In order to reduce the ulcerogenic effect of ibuprofen, its carboxylic group has been converted into 5-membered and 6-membered heterocyclic rings. Various 1,3,4-thiadaizo (y), imidazo [2,1-b] [1,3,4] thiadiazoles (1a-d), 1,3-oxazin-2-yl (2), quinazolin-2-yl (3, 4 and 5), hydrazine, pyrazole (6), pyrazone (7, 8) and oxadiazole (9, 12). Derivatives of ibuprofen were prepared by cyclization under various reaction conditions in a very good yield. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity. Compounds (4, 5, and 8) showed the highest antibacterial activities compared to other compounds and standard drugs. However, compound (1b) showed the lowest antibacterial activity compared to other compounds. All compounds have been characterized by IR, 1H NMR and C.H.N analysis.