TITLE:
Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes
AUTHORS:
Anissa Messaaoui, Sylvie Tenoutasse, Christian Mélot, Harry Dorchy
KEYWORDS:
Type 1 Diabetes, Hyperfiltration, Nephropathy, C-Peptide, Glycated Hemoglobin
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.1,
February
14,
2014
ABSTRACT: Background: Increased
glomerular filtration rate (GFR) commonly develops in early diabetes and is
closely correlated with the development of diabetic nephropathy. Objective: The
aim was to study the relationship between GFR, C-peptide level and other
parameters at diagnosis of Type 1 diabetes. Methods: We determined GFR, Cpeptide
level, glycated hemoglobin (HbA1c), body mass index (BMI) SDS and loss of
weight at diagnosis of Type 1 diabetes in 495 children (231 females). Linear
and multiple regression analysis was used to test for the associations between
GFR and other parameters. Results: In the 495 patients, GFR median
(interquartile range) was increased vs normal values (p = 0.0001). GFR was
significantly negatively correlated with age (p