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Robinson, J., Hartling, L., Vandermeer, B., Crumley, E. and Klassen, T.P. (2005) Intravenous immunoglobulin for presumed viral myocarditis in children and adults. Cochrane Database of Systematic Reviews, 25, Article ID: CD004370.

has been cited by the following article:

• TITLE: Effect of intravenous gamma globulin on short- and mid-term clinical outcome in acute viral myocarditis in children

  AUTHORS: Mehnaz Atiq, Mehar Hoda, Nadeem Aslam

  KEYWORDS: Acute Myocarditis; Intravenous Gamma Globulins; Congestive Heart failure

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.4 No.2, February 12, 2014

  ABSTRACT: Acute viral myocarditis is an extremely diverse disease with a predictable good outcome with supportive therapy. The objective of this study was to look at the clinical outcome of patients receiving additional intravenous gamma globulin compared to those receiving conventional anti-congestive therapy alone. Patients and methods: This is a retrospective review of charts of children admitted with acute myocarditis. Group 1 was children who received intravenous gamma globulin (IVIG) along with conventional anti-congestive therapy. Group 2 were patients who received the conventional anticongestive therapy alone. Short-term outcome was survival to hospital discharge, and mid-term outcome was improvement of left ventricular ejection fraction at 6 months and one year follow-up. Results: A total of 36 patients were enrolled and 18 were males. The mean age of all patients was 2.3 ± 2.6 years and the mean duration of illness for the whole group was 6.7 ± 3.8 days. Group 1 comprised of 16 patients. There was no difference in short-term outcome with mortality of 2 patients in Group1 (12.5%) and 3(15%) in Group 2 (p = 0.2). At intermediate term follow up, recovery of ejection fraction in Group 1 was in 4/14 (28%) and in Group 2 it was 9/17 (55%) and at 12 months it was 10/13 (77%) in Group 1 and 15/16 (94%) in Group 2 (p = 0.02 and 0.19 respectively). Conclusion: Acute myocarditis has a high spontaneous cure rate. Our study did not show any significant difference in the short-term or midterm outcome between children receiving IVIG compared to those who did not.