TITLE:
Plants: The Future Pharmaceutical Factory
AUTHORS:
Bipradut Sil, Sumita Jha
KEYWORDS:
PMPs; Production Platform; Pharmaceuticals; Transformation; Gene Expression
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.5 No.3,
February
8,
2014
ABSTRACT: The main objective of this study was to identify
prospects, advantages and challenges of plant molecular farming. Plant-made
pharmaceuticals (PMPs) and plant made vaccines (PMVs) were intended to be used for human consumption. A broad range of plants, including
crops, vegetables and fruits have been investigated for their applicability in production of pharmaceuticals over the
last two decades. At present, mainly maize, rice, tobacco and safflower are
used in open field production. Contained bioreactor-type systems focus on moss,
algae and plant organ culture. Expression systems include stable transformation
of plant genomes—both nuclear and plastid, which are also used in
the generation of genetically modified crops, plant-viruses and transient
expressions. Each expression system (production platform) offers
different advantages and disadvantages. Production platform choice is
perceptive and depends on a broad range of criterion. This study is based on
literature reviews, document analysis
and internet database browsing.