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Suárez, C., Vizoso, F., Rodríguez, J.C., García, I., Raigoso, P., Allende, M.T., García-Muíz, J.L. and GarcíaMorán, M. (2001) Prognostic significance of cytosolic pS2 protein con-tent in gastric cancer. The International Journal of Biological Markers, 16, 37-44

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• TITLE: Effects of Anwei decoction on the protein expression of TFF in rats with chronic atrophic gastritis

  AUTHORS: Wei Wei, Shouning Lin, Yongping Zhu

  KEYWORDS: Anwei Decoction; Atrophic Gastritis; TFF1; TFF2; TFF3; Experimental Research

  JOURNAL NAME: Modern Research in Inflammation, Vol.3 No.1, February 7, 2014

  ABSTRACT: Objective: To explore the effects of Anwei decoction (AD) on the protein expression of TFF in rats with chronic atrophic gastritis(CAG). Methods: Forty-eight healthy rats were randomly divided into 4 groups: normal control group, pathologic model group, Anwei Decoction group, and Weifuchun group. CAG was induced in rats with N-methy-N-nitro-N-nitrogua-nidine (MNNG). The protein expression of TFF in rats’ gastric mucosa was determined by immunohistochemistry. Results: Compared with that in the normal control group, the protein expression of TFF1 was significantly enhanced in the pathologic model, Anwei Decoction and Weifuchun groups (both P TFF1 was significantly higher in the Anwei Decoction group than in the Weifuchun group (P protein expression of TFF3 was remarkably reduced in Anwei Decoction and Weifuchun groups (both P 0.05). Conclusion: Anwei decoction may be effective in the treatment of CAG by enhancing the protein expression of TFF1, TFF2 while reducing that of TFF3 in gastric mucosas.