TITLE:
Effects of Anwei decoction on the protein expression of TFF in rats with chronic atrophic gastritis
AUTHORS:
Wei Wei, Shouning Lin, Yongping Zhu
KEYWORDS:
Anwei Decoction; Atrophic Gastritis; TFF1; TFF2; TFF3; Experimental Research
JOURNAL NAME:
Modern Research in Inflammation,
Vol.3 No.1,
February
7,
2014
ABSTRACT: Objective:
To explore the effects of Anwei decoction (AD) on the protein expression of TFF
in rats with chronic atrophic gastritis(CAG). Methods: Forty-eight healthy rats
were randomly divided into 4 groups: normal control group, pathologic model
group, Anwei Decoction group, and Weifuchun group. CAG was induced in rats with
N-methy-N-nitro-N-nitrogua-nidine (MNNG). The protein expression of TFF in
rats’ gastric mucosa was determined by immunohistochemistry. Results: Compared
with that in the normal control group, the protein expression of TFF1 was
significantly enhanced in the pathologic model, Anwei Decoction and Weifuchun
groups (both P TFF1 was significantly higher in the Anwei Decoction
group than in the Weifuchun group (P protein
expression of TFF3 was remarkably reduced in Anwei Decoction and
Weifuchun groups (both P 0.05). Conclusion:
Anwei decoction may be effective in the treatment of CAG by enhancing the
protein expression of TFF1, TFF2 while reducing that of TFF3 in gastric mucosas.