Article citationsMore>>

C. L. Sprung, D. Annane, D. Keh, R. Moreno, M. Singer, K. Freivogel, Y. G. Weiss, J. Benbenishty, A. Kalenka, H. Forst, P. F. Laterre, K. Reinhart, B. H. Cuthbertson, D. Payen and J. Briegel, “Hydrocortisone Therapy for Patients with Septic Shock,” New England Journal of Medicine, Vol. 358, No. 2, 2008, pp. 111-124. doi:10.1056/NEJMoa071366

has been cited by the following article:

• TITLE: Corticosteroids and ICU Course of Community Acquired Pneumonia in Egyptian Settings

  AUTHORS: Nirmeen A. Sabry, Emad El-Din Omar

  KEYWORDS: Community-Acquired Pneumonia, Corticosteroids, Hydrocortisone, Pneumonia

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.2 No.2, March 30, 2011

  ABSTRACT: Background: Pneumonia is the most common cause of community-acquired infection requiring ICU admission. 60-87% of patients with severe community acquired pneumonia (CAP) admitted to the ICU develops respiratory failure and require mechanical ventilation (MV). Objectives: To assess the efficacy and safety of adjunctive low dose hydrocortisone infusion treatment in Egyptian ICU patients with CAP. Methods: Hospitalized patients, clinically and radiologically diagnosed with CAP, were randomized to receive hydrocortisone 12.5 mg/h IV infusion for 7 days or placebo, along with antibiotics. The end-points of the study were improvement in PaO2:FIO2 (PaO2:FIO2 > 300 or ≥100 increase from study entry) and SOFA score by study day 8 and the development of delayed septic shock. Results: 80 patients were recruited, 40 of them received hydrocortisone and the remaining 40 received placebo. By study day 8, hydrocortisone treated patients showed a significant improvement in PaO2:FIO2 and chest radiograph score, and a significant reduction in C-reactive protein (CRP) levels, Sepsis-related Organ Failure Assessment (SOFA) score, and delayed septic shock compared to the control group. Hydrocortisone treatment was associated with a significant reduction in the duration of MV. However, hydrocortisone infusion did not show significant difference in the ICU mortality. Conclusions: adjunctive 7-day course of low dose hydrocortisone IV in patients with CAP hastens recovery of pneumonia and prevents the development of sepsis related complications with a significant reduction in duration of the mechanical ventilation.