TITLE:
IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor in the vitreous of patients with proliferative diabetic retinopathy
AUTHORS:
Valery Chernykh, Evgeny Smirnov, Yegor Varvarinsky, Dmitry Chernykh, Olga Obukhovа, Aleksandr Trunov
KEYWORDS:
Diabetic Retinopathy; Cytokines; Vascular Endothelial Growth Factor
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.3,
January
29,
2014
ABSTRACT: In current article, results of the determination of
the concentrations of vascular endothelial growth factor (VEGF), and some
interleukins (IL-4, IL-6, IL-10, IL-17А) in the vitreous of patients with
proliferative diabetic retinopathy are presented. We have found that in the
mechanism of development of diabetic retinopathy, significant role plays an activation
of local inflammation process and vascular proliferation. This is evidenced by
a significant increase in the vitreous concentration of IL-4, IL-6, IL-10,
IL-17A and vascular endothelial growth factor. Identified correlations between
VEGF and IL-17A, between VEGF and IL-4, and between IL-17A and IL-4 show the
relationship of inflammation and proliferation processes in the pathogenesis of
diabetic retinopathy.