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D. F. Kallmes, B. A. Comstock, P. J. Heagerty, P. J. Heagerty, J. A. Turner, D. J. Wilson, T. H. Daiamond, R. Edwards, L. A. Gray, L. Stout, S. Owen, W. Hollingworth, B. Ghdoke, D. J. Annesley-Williams, S. H. Ralston and J. G. Jarvik, “A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures,” The New England Journal of Medicine, Vol. 361, No. 6, 2009, pp. 569-579. http://dx.doi.org/10.1056/NEJMoa0900563

has been cited by the following article:

• TITLE: Vertebral Bone Drilling (Puncture) Attenuates the Acute Pain Due to Vertebral Compression Fractures

  AUTHORS: Koichi Ota, Sosi Iwasaki

  KEYWORDS: Vertebral Bone Drilling; Osteoporosis; Vertebral Compression Fractures; Acute Pain; Vertebroplasty

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.4 No.2, January 29, 2014

  ABSTRACT: Purpose: The Investigational Vertebroplasty Efficacy and Safety Trial (INVEST), a randomized blinded controlled study of Vertebroplasty, demonstrated similar improvements in pain between blinded Vertebroplasty and sham-Vertebroplasty groups. The result from the RCT study suggested that the observed efficacy of the Vertebroplasty procedure, instead of representing the cement-mediated reduction in pain, may relate to the vertebral bone drilling per se. The aim of this study was to demonstrate the effectiveness of pain relief of vertebral bone drilling at the site of painful osteoporotic vertebral compression fractures in the acute phase. Materials and Methods: Twenty-six patients with painful osteoporotic compression fractures underwent the vertebral bone drilling. We assessed primary outcome measures in the NRS pain score and RDQ score at day 0 and 3 following the drilling. Comparisons were made by using Wilcoxon signed rank test. Results: The mean baseline NRS and RDQ score, and the mean NRS and RDQ score at day 3 were 7.3 ± 1.2, 15.7 ± 4.2, 4.6 ± 1.4, 7.3 ± 2.2, respectively. Among the patients, we detected significant improvements in NRS pain score and RDQ score at day 3 following the drilling compared with day 0 (P al compression fractures alleviated the intractable pain due to osteoporotic vertebral compression fractures.