TITLE:
Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer
AUTHORS:
Rossella Di Franco, Vincenzo Ravo, Sara Falivene, Angela Argenone, Valentina Borzillo, Francesca Maria Giugliano, Elena Sammarco, Matteo Muto, Salvatore Cappabianca, Paolo Muto
KEYWORDS:
Skin Toxicity; Prevention and Treatment; Radiotherapy
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.1,
January
28,
2014
ABSTRACT: Introduction: Skin toxicity is a frequent side
effect of radio and chemo-treatments in patients treated for breast cancer
after conservative surgery. The aim of this paper is to report our experience
in the management of skin toxicity evaluating radiotherapy planning and using
preventive local aids. Materials and Methods: We have observed 300 patients undergoing
radiotherapy. All received the prescription of a prophylactic moisturizing
cream. Skin toxicity was valuated according to Acute Radiation Morbidity
Scoring Criteria of the RTOG. Moreover, in a subgroup of 100 patients, we
correlated the study of breast volume and features of treatment plans, with the
addition of topic prophylactic treatment, using an oral therapy based on
Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?). In
another subgroup, 100 patients were subjected to corneometry assessing
numerically skin hydration before, during and after radiotherapy. Results: In
all patients, we related skin toxicity and the type of cream used. All patients
completed the radiotherapy treatment, and G4 cutaneous toxicity was not observed
in any of them. In patients treated with topic treatment and therapy based on
Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?), the
protective effect of (Ixor?) is more detected in patients with PTV
(Planning Target Volume)