TITLE:
Protective Effects of a Novel Preparation Consists of Concentrated Dead Sea Water and Natural Plants Extracts against Skin Photo-Damage
AUTHORS:
Meital Portugal-Cohen, Isabelle Afriat-Staloff, Yoram Soroka, Marina Frusic-Zlotkin, Gerrit Schlippe, Werner Voss, Ze’evi Ma’or
KEYWORDS:
Photo-Damage; Skin Dryness; Skin Barrier Function; Skin Detoxification; Dead Sea Minerals
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.1,
January
26,
2014
ABSTRACT: Background: Exposure to solar UV rays has deleterious
effects on skin appearance through physiological and structural alterations
that eventually lead to skin photo-damage. Aims: To test the photo-protective effect of a novel preparation,
Dead Sea Osmoter Concentrate (DSOC), containing
high concentration of Dead Sea water. Methods:
Human skin organ culture was used as a model to assess the biological effects
of UVB irradiation and the protective effect of topical application of DSOC
preparation. Skin pieces were analyzed for mitochondrial activity by Alamar
blue (resazurin) assay, for apoptosis by caspase 3 assay, for detoxification by
proteasome 20S sub-unit activity and for skin hydration by aquaporin 3 (AQP3)
membrane channels expression. Human subjects were tested to evaluate the effect
of DSOC Serum, a topical formula for facial skin, on skin hydration by a corneometer.
Results: UVB irradiation induced
cell apoptosis in the epidermis of skin organ cultures and decreased their
proteasome activity and AQP3 expression. Topical application of DSOC
significantly attenuated all these effects. In human subjects, an elevation in
the intense skin moisture, which was higher relatively to subjects’ regular
moisturizer, was observed. Moreover, DSOC Serum boosted the hydration effect
together with regular moisturizer. Conclusions:
The results clearly demonstrate that DSOC preparation can significantly improve
the skin capability in coping with UVB rays stress in different cellular
functions such as anti-apoptotic properties as well as detoxification and
hydration recovery that can attenuate biological effects of skin photo-damage.
Topical application of DSOC Serum had contributed to skin appearance by a
strong hydration impact, also as a booster.