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M. Mora, S. J. Medina-Leendertz, E. Bonilla, R. E. Terán, M. C. Paz and J. L. Arcaya, “Minocycline, but Not Ascorbic Acid, Increases Motor Activity and Extends the Life Span of Drosophila melanogaster,” Investigación Clínica, Vol. 54, No. 2, 2013, pp. 161-170.

has been cited by the following article:

• TITLE: Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model

  AUTHORS: Valeriya Navrotskaya, Gregory Oxenkrug, Lyudmila Vorobyova, Paul Summergrad

  KEYWORDS: Berberine; Life Span; Drosophila Melanogaster; High Temperature; Kynurenine

  JOURNAL NAME: American Journal of Plant Sciences, Vol.5 No.3, January 26, 2014

  ABSTRACT: We have observed that berberine prolonged life span and improved viability of pupae and climbing activity of imagoes of wild-type Drosophila melanogaster maintained at 23°C. As a continuation of our studies of berberine effect on life span, we were interested to evaluate the effect of berberine of life span in flies maintained at a higher temperature (28°C) known to accelerate aging in wild type flies. Considering that genetically or pharmacologically induced deficiency of TRP conversion into KYN prolonged life span in a Drosophila model, we compared the effects of berberine, a powerful inhibitor of kynurenine (KYN) formation from tryptophan (TRP), on life span in wild type and in Drosophila melanogaster mutants (vermilion) with deficient TRP-KYN metabolism maintained at 23°C and 28°C. High (28°C) ambient temperature decreased life span in both wild type and vermilion flies. Aging accelerating effect of high temperature was more pronounced in Oregon than in vermilion flies (-60% vs. -40% decrease of mean life span, resp). Berberine attenuated the aging-accelerating effect of high temperature. Effect of berberine was more pronounced in Oregon (+46%) than in vermilion (+22%) flies. The obtained data suggested the possible involvement of TRP-KYN metabolism in the aging-acceleration effect of the high temperature and in protective effect of berberine.