TITLE:
Antimicrobial susceptibility of strains of Enterobacteriaceae isolated from bloodstream infections using current CLSI and EUCAST breakpoints
AUTHORS:
Giovanna Blandino, Silvana Mastrojeni, Rosanna Inturri, Agata Sciacca, Giuseppe Nicoletti
KEYWORDS:
Antimicrobial-Susceptibility; CLSI Breakpoints; EUCAST Breakpoints; Enterobacteriaceae; Bloodstream-Infections
JOURNAL NAME:
Health,
Vol.6 No.2,
January
26,
2014
ABSTRACT: Understanding local susceptibility patterns is
important when selecting antimicrobials for initial empirical
antibiotic-therapy of bloodstream infections. Because the determination of susceptibility
is dependent on the breakpoints used, the aim of the study was to compare the
antimicrobial susceptibility results to different classes of antibiotics of 512
strains of Enterobacteriaceae (200 ESβL positive) isolated from bloodstream
using CLSI 2013 and current EUCAST 2013 guidelines to evaluate the impact of
break-point discrepancies. The results of the study showed that statistically
significant discrepancies (p ≤ 0.001)
were found for amoxicillin/clavulanic acid, piperacillin alone or with
tazobac-tam, imipenem, meropenem, cefepime (only ESβL negative isolates),
amikacin and gentamicin using current CLSI or EUCAST interpretive criteria.
Further harmonization of CLSI and EUCAST breakpoints is warranted. This study
could give useful information to physicians for managing bloodstream infections
caused by Enterobacteriaceae.