TITLE:
A comprehensive meta-analysis of the association between three IL1B polymorphisms and rheumatoid arthritis
AUTHORS:
Dongjun Dai, Lingyan Wang, Limin Xu, Lingling Tang, Xuting Xu, Huadan Ye, Xingyu Zhou, Cheng Chen, Guanghui Pan, Ping Ru, Qingqing Ma, Yi Jiang, Wenjing Yu, Leiting Xu, Meng Ye, Shiwei Duan
KEYWORDS:
Rheumatoid Arthritis; Meta-Analysis; Polymorphism; IL1B-511; Dominant Model
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.2,
January
24,
2014
ABSTRACT: Rheumatoid arthritis (RA) is an immune-mediated
chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role
in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate
the association between IL1B polymorphisms and RA. A meta-analysis was performed on the
association between three IL1B polymorphisms
(IL1B-31: rs1143627; IL1B-511: rs16944; IL1B + 3954: rs1143634) and RA. A trend
of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in
Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T
played a protective role against RA in Europeans, and that IL1B + 3954-T had the
potential to increase the risk of RA. Future large-scale studies should be
considered to confirm the association between IL1B polymorphisms and
RA.