TITLE:
Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia
AUTHORS:
Xuting Xu, Lingyan Wang, Qi Liao, Leiting Xu, Yi Huang, Fuqiang Zhang, Jia Cheng, Meng Ye, Shugui Gao, Shiwei Duan
KEYWORDS:
Schizophrenia; Meta-Analysis; SNP
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.2,
January
24,
2014
ABSTRACT: The aim of this study was
to determine whether 9 genetic polymorphisms confered susceptibility to
schizophrenia (SCZ). The authors conducted meta-analyses on associations
between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1
(C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340,
rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our
results showed no significant association between all the loci and SCZ.
This meta-analysis confirmed a lack of association of SCZ for 9 genetic
polymorphisms including GRIN1 G1001C, ABCB1
C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340,
rs3749034 and rs769395, and PIK3C3 432C > T.