TITLE:
Role of toll receptors in diabetic nephropathy
AUTHORS:
Mona Mansour, Randa Fayez Salam, Lila Rashed, Heba Salam
KEYWORDS:
Diabetic Nephropathy; Toll Receptor 2, 4
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.1,
January
20,
2014
ABSTRACT: Objectives: Diabetic nephropathy is the leading cause of chronic kidney
disease. The pathogenesis of DN remains incompletely understood. It has been
recently demonstrated that inflammatory processes play a significant role in
the development and progression of DN. Toll-like receptors play a fundamental
role in the innate immune system by triggering proinflammatory signaling
pathways. Our aim is to evaluate the expression of TLRs on monocytes and relate
their expression with inflammation in HD patients with & without diabetic
nephropathy. Method: In a case
control study (60) patients from Alkasr El Aini Hospital on hemodialysis were divided
into two groups: Group 1, 30 patients on heamodialysis not due to diabetic
nephropathy, Group 2, 30 patients on heamodialysis due to diabetic nephropathy,
compared to Group 3, including 30 healthy controls. All participants were
subjected to: Full medical history, complete physical examination, Serum
creatinine, uric acid, A1C, fundus examination, detection of TLR2, TLR
expression by real time PCR in peripheral blood mononuclear cells. Data were
statically calculated using SPSS, comparision between groups was done using
student T test comparing 2 groups, correlation using spearman’s correlation. Results: Diabetic had significantly
increased TLR2, TLR4 mRNA in peripheral blood mononuclear cells compared to
controls and non diabetics patient on heamodialysis (p