TITLE:
On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles
AUTHORS:
Badiaa Fasla, Reda Benmouna, Mustapha Benmouna
KEYWORDS:
Hyper Thermal Therapy; Gold Nano Particles; Plasmon Resonance; Laser Heating
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.5 No.1,
January
17,
2014
ABSTRACT: Hyper thermal therapy using lasers is
emerging as a new promising route for the cancer
treatment. The tumor can be directly heated by the
radiation or indirectly using gold nano particles based on plasmon
resonance phenolmenon. These two possibilities are explored here by solving the space and time
dependent bio-heat equation under different
conditions. The knowledge of temperature profiles in the tumor region helps to
bypass the painful placement of sensors for
monitoring tumor’s heating by the laser. Important properties which could be
useful for developing an efficient tumor therapy are introduced for the first
time. It is found that the effects of metabolism consist
essentially in a redefinition of the blood temperature which increases
proportional to the heat of metabolism. Blood perfusion in a given
tissue leads to a new characteristic length of order one or two centimeters and
a blood convection parameter typically of order 30 W·m-1·K-1. Effects of these parameters are
scrutinized within the resolution of the bio-heat equation
under a variety of conditions. In general, space modulations of the temperature
throughout biological tissues are weak but front kinetics are quite fast.
Specific examples show the way to monitor the temperature rise taking into
account the tumor’s nature and size.