Article citationsMore>>

I. H. El-Sayed, X. Huang and M. A. El-Sayed, “Selective Laser Photo-Thermal Therapy of Epithelial Carcinoma Using Anti-EGFR Antibody Conjugated Gold Nanoparticles,” Cancer Letters, Vol. 239, No. 1, 2006, pp. 129-135. http://dx.doi.org/10.1016/j.canlet.2005.07.035

has been cited by the following article:

• TITLE: On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles

  AUTHORS: Badiaa Fasla, Reda Benmouna, Mustapha Benmouna

  KEYWORDS: Hyper Thermal Therapy; Gold Nano Particles; Plasmon Resonance; Laser Heating

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.5 No.1, January 17, 2014

  ABSTRACT: Hyper thermal therapy using lasers is emerging as a new promising route for the cancer treatment. The tumor can be directly heated by the radiation or indirectly using gold nano particles based on plasmon resonance phenolmenon. These two possibilities are explored here by solving the space and time dependent bio-heat equation under different conditions. The knowledge of temperature profiles in the tumor region helps to bypass the painful placement of sensors for monitoring tumor’s heating by the laser. Important properties which could be useful for developing an efficient tumor therapy are introduced for the first time. It is found that the effects of metabolism consist essentially in a redefinition of the blood temperature which increases proportional to the heat of metabolism. Blood perfusion in a given tissue leads to a new characteristic length of order one or two centimeters and a blood convection parameter typically of order 30 W·m-1·K-1. Effects of these parameters are scrutinized within the resolution of the bio-heat equation under a variety of conditions. In general, space modulations of the temperature throughout biological tissues are weak but front kinetics are quite fast. Specific examples show the way to monitor the temperature rise taking into account the tumor’s nature and size.