TITLE:
Single Nucleotide Polymorphisms and Haplotypes in Vascular Endothelial Growth Factor Gene and Residual Ridge Resorption of Mandible in Korean Population
AUTHORS:
Jung-Hyun Song, Jae-Hoon Lee
KEYWORDS:
SNP; VEGF; Haplotype; Residual Ridge Resorption; Edentulous Mandible
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.5 No.1,
January
16,
2014
ABSTRACT: The tooth extraction is
a routine surgical procedure in the dental
treatment where the healing process results in a saddle-shaped residual ridge
in the edentulous jaw. There are substantial differences among individuals in
the end result. In some cases, there is
excessive bone atrophy, which complicates the dental
restorative treatment. The
alveolar ridge receives the mechanical load continuously from the periodontal
ligament connected to the teeth and it diminishes dramatically as a consequence
of dental extraction; thus it is
believed the continuing pattern of the alveolar bone resorption is related to this
change. The reduced partial pressure of oxygen is the most prominent event from
the reduced mechanical load. Vascular
Endothelial Growth Factor (VEGF), regulated by HIF-1, reported close
association with angiogenesis and bone turn over, where partial oxygen pressure
has changed. Therefore the genetic
association between Single Nucleotide Polymorphsim (SNP) of VEGF gene and RRR
was investigated. 120 subjects (70.93 ± 9.28 years) which were treated at Dental clinic of Yonsei
University with edentulous mandible were recruited. Mandibular bone height was
measured following the protocol of the American College of Prosthodontists. Three variants, rs1570360,
rs25648, and rs3025039 in VEGF from previous study, were used as tag-SNPs and genotyping for the
study. Student’s t-test and ANOVA were used for statistical analysis. There was a notable association with
rs1570360 (P = 0.051) in
dominant group and haplotype A-C-C showed a statistically
significant association with RRR in dominant group (P = 0.042). Results of this study may be useful in
developing novel genetic diagnostic tests and identifying Koreans susceptible
to developing severe RRR after dental extraction.