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B. S. Carson, J. H. Anderson, S. A. Grossman, J. Hilton, C. L. White 3rd, O. M. Colvin, et al., “Improved Rabbit Brain Tumor Model Amenable to Diagnostic Radiographic Procedures,” Neurosurgery, Vol. 11, No. 5, 1982, pp. 603-608. http://dx.doi.org/10.1227/00006123-198211000-00003

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• TITLE: Intramedullary Spinal Cord Glioma Following Microinjection of Glioblastoma Cell Line C6 in Rats

  AUTHORS: Yasar Dagistan, Gulzade Ozyalvacli, Tulin Firat, Kaan Yagmurlu, Elcin Hakan Terzi

  KEYWORDS: Intramedullary Spinal Cord Glioma; Animal Model; C6 Glioblastoma Cell

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.4 No.1, January 16, 2014

  ABSTRACT: Background: This paper describes the establishment of a rat intramedullary spinal cord tumor (IMSCT) model and histopathological characterization of the tumor model. Methods: Fourteen male Wistar rats were randomized into two groups. The rats in group 1 (control group, n = 7) received a 5 μl intramedullary injection of serum physiologic (SF). Those in group 2 (experimental group, n= 7) received a 5 μl intramedullary implantation of media containing 5 × 105 C6 glioma cells. The animals were sacrificed for histopathological examination at 21 days. Results: The control group showed normal functional and histopathological findings. The group 2 rats implanted with C6 glioblastoma cells developed hind-limb paraplegia. Pathological sections confirmed intramedullary C6 glioblastoma invading the spinal cord. Conclusions: A rat C6 IMSCT model was successfully established. This model may be useful in increasing understanding of intramedullary spinal cord gliomas in humans.