Article citationsMore>>

G. B. Rodrigues, J. N. Waldron, S. Wong and N. J. Laperriere, “A Retrospective Analysis of 52 Cases of Spinal Cord Glioma Managed with Radiation Therapy,” International Journal of Radiation Oncology, Biology and Physics, Vol. 48, No. 3, 2001, pp. 837-842. http://dx.doi.org/10.1016/S0360-3016(00)00690-8

has been cited by the following article:

• TITLE: Intramedullary Spinal Cord Glioma Following Microinjection of Glioblastoma Cell Line C6 in Rats

  AUTHORS: Yasar Dagistan, Gulzade Ozyalvacli, Tulin Firat, Kaan Yagmurlu, Elcin Hakan Terzi

  KEYWORDS: Intramedullary Spinal Cord Glioma; Animal Model; C6 Glioblastoma Cell

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.4 No.1, January 16, 2014

  ABSTRACT: Background: This paper describes the establishment of a rat intramedullary spinal cord tumor (IMSCT) model and histopathological characterization of the tumor model. Methods: Fourteen male Wistar rats were randomized into two groups. The rats in group 1 (control group, n = 7) received a 5 μl intramedullary injection of serum physiologic (SF). Those in group 2 (experimental group, n= 7) received a 5 μl intramedullary implantation of media containing 5 × 105 C6 glioma cells. The animals were sacrificed for histopathological examination at 21 days. Results: The control group showed normal functional and histopathological findings. The group 2 rats implanted with C6 glioblastoma cells developed hind-limb paraplegia. Pathological sections confirmed intramedullary C6 glioblastoma invading the spinal cord. Conclusions: A rat C6 IMSCT model was successfully established. This model may be useful in increasing understanding of intramedullary spinal cord gliomas in humans.