TITLE:
Poly(Vinyl Alcohol)/Collagen/Hydroxyapatite Nanoparticles Hybrid System Containing Yttrium-90 as a Potential Agent to Treat Osteosarcoma
AUTHORS:
Marcelo F. Cipreste, Edesia M. B. Sousa
KEYWORDS:
Osteosarcoma; Hydroxyapatite Nanoparticles; PVA; Collagen; Yttrium-90
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.5 No.1,
January
16,
2014
ABSTRACT: Osteosarcoma is the most
common primary malignant bone tumors, affecting mostly children, adolescents
and young adults. This is an aggressive tumor that results in a high mortality
rate and poor prognosis. Due to the low sensitivity of osteosarcoma to ionizing
radiation, such treatment is not used very often and it can be recommended only to postsurgical therapy. As an
alternative therapy, functionalized nanomaterials allow their accumulation in tumor tissues due to their unique
properties, making them good agents to act as stable carriers for
radionuclides. In this work, mesoporous hydroxyapatite nanoparticles were
synthesized and the functionalization process with poly(vinyl alcohol) and collagen was investigated.
The samples were characterized by X-ray diffraction (XRD), N2 adsorption, elemental analysis (CHN),
Fourier Transform Infrared Spectroscopy (FTIR), Nitrogen Adsorption, Transmission Electron Microscopy (TEM), and Thermal
Analysis. Also, the yttrium incorporation potential and its release kinetics in the hydroxyapatite matrix were evaluated to study the
capacity of this system to treat osteosarcomas. The results indicate that this
material has a promisor potential to treat this kind of tumor.