TITLE:
Neuroprotective effect of panax notoginseng saponins and its main components
AUTHORS:
Xumei Wang, Shaoxia Wang, Limin Hu
KEYWORDS:
Panax Notoginseng Saponins; Cerebral Ischemia; Neuro-Protection; Neuron Regeneration
JOURNAL NAME:
World Journal of Neuroscience,
Vol.4 No.1,
January
16,
2014
ABSTRACT: Stroke is the third
leading cause of death and the first cause of adult disability in industrial
countries [1]. It is charicaterized by hemiplegia, hemianopsia, aphasia, mouth
askew and sever sequelae. It is considered that an ischemic disease without any
specific treatment method and few effective drugs such as tPA (human
tissue-type plasminogen activator) and Edarovone with specific therapeutic
window will cause a lot of disadvantages if being used inaccurate. Root of
Panax notoginseng (PN) which is one of traditional Chinese medicines (TCMs),
was first found in “Shennong’s Classic of Materia Medica” around 200 AD. Panax
notogineng saponins(PNS) is a multi-components mixture containing ginseng and
saponins as the most important bioactive components which are commonly used in
clinical treatment. Also, ginseng and saponins form the main components of many
herbal medicines in the market, e.g., Xueshuantong injection [2], Xuesaitong
injection [3], Xuesaitong soft capsule [4] and so on. The main monomers of
Panax notoginseng saponins (PNS) are
Ginsenoside-Rb1, Gensenoside-Rg1, Gensenoside-Re, Gensenoside-Rd and
Panax notoginseng saponins-R1 [5]. In this review, we found some important
points as well as shortcomings that require special
consideration. We therefore highlighted the advances in
neuro-protection of PNS and its main monomers in the area of experimental
research.