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K. Umehara, M. Nakamura, T. Miyase, M. Kuroyanagi and A. Ueno, “Studies on Differentiation Inducers: VI. Lignan Derivatives from Arctium Fructus (2),” Chemical & Pharmaceutical Bulletin, Vol. 44, No. 12, 1996, pp. 2300-2304.

has been cited by the following article:

• TITLE: Induction of Apoptosis and Acetylation of Histone H3 and H4 by Arctigenin in the Human Melanoma Cell Line SK-MEL-28

  AUTHORS: Jin Boo Jeong, Se Chul Hong, Jin Suk Koo, Hyung Jin Jeong

  KEYWORDS: Arctigenin, Apoptosis, Histone Acetylation, Caspases, Melanoma

  JOURNAL NAME: Food and Nutrition Sciences, Vol.2 No.2, March 31, 2011

  ABSTRACT: Cutaneous melanoma is one of the most aggressive forms of skin cancer. Arctigenin, one of the major bioactive compo-nents of Arctii Fructus, has been reported to exhibit antioxidant, antitumor and anti-inflammatory activities. In the pre-sent study, we investigated the effect of arctigenin on induction of apoptosis in highly metastatic SK-MEL-28 human melanoma cells. Arctigenin inhibited growth of SK-MEL-28 cells in a dose-dependent manner. Treatment of SK-MEL-28cells with arctigenin caused cleavage of caspases 3, 7 and 9, and poly (ADP-ribose) polymerase in a dose-dependent manner. Furthermore, acetylation of histone H3 and H4 in the SK-MEL-28 cells was dramatically increased by arctigenin treatment. Collectively, these findings indicate that arctigenin-induces apoptosis of SK-MEL-28 melanoma cells via activation of caspases and histone acetylation.