TITLE:
Nitridergic Modulation of the Antinociceptive Activity of Rosuvastatin in Mice
AUTHORS:
Viviana Noriega, Fernando Sierralta, Juan Carlos Prieto, Pilar Zanetta, Hugo F. Miranda
KEYWORDS:
Antinociception; Anti-Inflammation; Algesiometer Assays; Rosuvastatin; L-NAME; Aminoguanidine
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.1,
January
15,
2014
ABSTRACT: Statins, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase enzyme
inhibitors, are lipid-lowering drugs, often used in the treatment of
cardiovascular diseases (hyperlipidemia, atherosclerosis). It has been shown
that statins have antiinflammatory effects independent of their lipid-lowering
effects and these anti-inflammatory effects inhibit the inflammation and pain
process. This study evaluated
the antinociceptive and anti-inflammatory effects of rosuvastatin using the
acetic acid writhing, the formalin hind paw, the orofacial formalin and the hot
plate tests. The following experimental group were used: control, acute (1 day) and chronic (3 days) after oral gavage with
rosuvastatin (3, 10, 30, 100 and 300 mg/kg). Rosuvastatin produced a
dose-dependent antinociception, with different potency, in all the tests.
Additionally, nitric oxide synthase inhibitors (Abbreviationsand
aminoguanidine) were used to assess the nitric oxide participation on this
induced rosuvastatin antinociception. The data demonstrated the antinociceptive
and anti-inflammatory activity of rosuvastatin in algesiometer models of tonic
or phasic pain. These activities seem to be induced
by modulation of iNOS expression, a result that may be relevant in the pharmacological
treatment of human pain where rosuvastatin and nitric oxide synthase inhibitors must be used.