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Wattig, B., Schalow, G., Madauss, M., Heydenreich, F., Warzok, R. and Cervós-Navarro, J. (1992) Acceleration of nerve and muscle regeneration by administration of nu- cleotides—Electroneurophysiological and morphometrical investigations. Acta Histochemica, 42, 333-339.

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• TITLE: Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin

  AUTHORS: Marco Antonio Mibielli, Carlos Pereira Nunes, Ari Boulanger Scussel Jr., Mendel Suchmacher Neto, Lisa Oliveira, Mauro Geller

  KEYWORDS: Uridine Triphosphate; Cytidine Monophosphate; Hydroxocobalamin; Analgesia

  JOURNAL NAME: Pain Studies and Treatment, Vol.2 No.1, January 15, 2014

  ABSTRACT: Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corroborate analgesiceffects of UTP, CMP and hydroxocobalamin combination in a self-paired evolutionary model. Methods: Mean VAS scores from pretreatment, V2 (5th treatment day) and V3 (10th treatment day) were plotted and statistically analyzed (ANOVA) for differences. PFQ scores from pretreatment, V2, and V3 were analyzed using the chisquare test. Results: The difference between V3 and pretreatment mean VAS scores was statistically significant (p