TITLE:
Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride
AUTHORS:
Karlen Hovnanyan, Vardan Mamikonyan, Anahit Margaryan, Kristine Sargsyan, Margarita Hovnanyan, Maria Karagyozyan, Konstantin Karageuzyan
KEYWORDS:
CCl4; GSE; α-Tocopherol; Ultrastructural Changes; Intoxicated Hepatocytes; Electron Microscopy
JOURNAL NAME:
Journal of Biophysical Chemistry,
Vol.5 No.1,
January
15,
2014
ABSTRACT: The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.