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K. Konno, H. Ono, M. Nakamura, K. Tateishi, C. Hirayama, Y. Tamura, M. Hattori, A. Koyama and K. Kohno, “Mulberry Latex Rich in Antidiabetic Sugar-Mimic Alkaloids Forces Dieting on Caterpillars,” Proceedings of National Academy of Sciences in USA, Vol. 103, 2006, pp. 1337-1341. doi:10.1073/pnas.0506944103

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• TITLE: 1-Deoxynojirimycin Content and Alfa-Glucosidase Inhibitory Activity and Heat Stability of 1-Deoxynojirimycin in Silkworm Powder

  AUTHORS: Kazuhisa Yatsunami, Kohji Murata, Tsutomu Kamei

  KEYWORDS: Silkworm, Bombyx Mori, 1-Deoxynojirimycin, Alfa-Glucosidase, Inhibitor, Heat Stability

  JOURNAL NAME: Food and Nutrition Sciences, Vol.2 No.2, March 31, 2011

  ABSTRACT: Silkworm powder containing 1-deoxynojirimycin (DNJ) has α-glucosidase inhibitory activity and is promising as a complementary and alternative medicine (CAM) agent in Japan. Silkworm powder produced in Korea was extracted with 75% ethanol. The extract was derivatized with 9-fluorenylmethyl chloroformate (FMOC-Cl), and DNJ-FMOC content was measured by HPLC. Then, alfa-glucosidase inhibition by silkworm and mulberry powder in pig liver crude enzyme was assayed using 4-nitrophenyl-alfa-D-glucopyranoside as a substrate. Silkworm powder DNJ content (0.39 to 0.58%) was higher than that in mulberry powder (0.08 to 0.12%). The alfa-glucosidase inhibitory activity of silkworm powder was more potent than that of mulberry leaves and green tea. Silkworm powder DNJ was stable upon heating to 121?C for up to 15 min.