TITLE:
Cognitive Deficits in Primary Brain Tumours: A Framework for Management and Rehabilitation
AUTHORS:
Michael Back, Elizabeth Back, Marina Kastelan, Helen Wheeler
KEYWORDS:
Glioma; Cognitive; Rehabilitation
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.1,
January
14,
2014
ABSTRACT: Cognitive deficits related to tumour or treatment are estimated to be
present in the majority of patients diagnosed with a primary brain tumour, with
a large variation based on tumour site, extent, and grade, as well as nature of
intervention. These deficits have a significant impact on patient’s quality of life and functional status. The improved patient survival
duration in recent years has increased the need to detect, understand and
intervene on these cognitive deficits, and optimise patient pathways for
treatment. This article reviews the nature of deficits arising in patients with
primary brain tumour, and the association of the deficits with neuroanatomical
site of tumour. The approach to interventions through adaptation and
remediation is outlined, with aim of improving function, promoting generalization
of outcomes and optimizing any neuroplasticity that may arise. The evidence for
pharmacological therapies and cognitive rehabilitation is presented, and a
framework for implementation is provided.