TITLE:
Diabetic cystopathy in children and adolescents with Type 1 diabetes mellitus
AUTHORS:
Mona A. K. Salem, Safinaz A. El Habashy, Dalia N. Toaima, Hassan S. Shaker, Osama M. A. H. Hetta, Jonair H. A. El Kafy
KEYWORDS:
Diabetic Cystopathy; Type 1 Diabetes; Diabetic Neuropathy; Urinary Bladder; Urodynamic Tests
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.1,
January
13,
2014
ABSTRACT: Background: Urinary bladder dysfunction is a
major complication of diabetes mellitus and its mechanism has been attributed
to autonomic and/or peripheral neuropathy. Objectives: Evaluation of diabetes
mellitus and neuropathy effect on the urinary bladder dynamics in children and
adolescents with Type 1 diabetes mellitus. Patients and Methods: The study
included 80 children and adolescents with Type 1 diabetes for at least 5 years;
60 patients were with manifestations of autonomic and/or peripheral neuropathy
and 20 patients were free of either. We assessed both groups for presence of cystopathy by means of uroflowmetry
and cystometry. Results: All patients with diabetic neuropathy had abnormal
urodynamic test results of variable types and degrees with bladder hypercompliance
as the most frequent abnormality. Other urodynamic abnormalities were found in
both diabetic patients’ groups with no significant difference in frequency.
Conclusions: Diabetic neuropathy might be strongly related to urodynamic
abnormalities particularly the bladder hypercompliance. Some diabetic patients
may have cystopathy in absence of evident neuropathy. This may be due to
undetected neuropathy or diabetes induced myopathy of the detrusor muscle.