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S. Akhondzadeh, M. Shafiee Sabet, M. H. Harirchian, M. Togha, H. Cheraghmakani, S. Razeghi, S. S. Hejazi, M. H. Yousefi, R. Alimardani, A. Jamshidi, S. A. Rezazadeh, A. Yousefi, F. Zare, A. Moradi and A. Vossoughi, “A 22-Week, Multicenter, Randomized, Double-Blind Controlled Trial of Crocus sativus in the Treatment of Mild-toModerate Alzheimer’s Disease,” Psychopharmacology, Vol. 207, No. 4, 2013, pp. 637-643.
http://dx.doi.org/10.1007/s00213-009-1706-1

has been cited by the following article:

• TITLE: Crocetin Prevents Amyloid β1-42-Induced Cell Death in Murine Hippocampal Cells

  AUTHORS: Yuta Yoshino, Mitsue Ishisaka, Naofumi Umigai, Masamitsu Shimazawa, Kazuhiro Tsuruma, Hideaki Hara

  KEYWORDS: Alzheimer’s Disease; Amyloid β1-42; Crocetin; HT22; Oxidative Stress

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.1, January 13, 2014

  ABSTRACT: Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ1-42. Furthermore, to clarify the mechanism underlying the protective effects of crocetin against Aβ1-42- induced cell death, we measured reactive oxygen species (ROS) production by CM-H2DCFDA kit assay. Crocetin at 1 -10 μM protected HT22 cells against Aβ1-42-induced neuronal cell death and decreased ROS production increased by Aβ1-42. These results that crocetin has the potent neuroprotective effect against Aβ1-42-induced cytotoxicity in hippocampal cells by attenuating oxidative stress, suggest that crocetin may provide a useful therapeutic strategy against Aβ-related disorders.