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S. Akhondzadeh, M. S. Sabet, M. H. Harirchian, M. Togha, H. Cheraghmakani, S. Razeghi, S. Hejazi, M. H. Yousefi, R. Alimardani, A. Jamshidi, F. Zare and A. Moradi, “Saffron in the Treatment of Patients with Mild to Moderate Alzheimer’s Disease: A 16-Week, Randomized and Placebo-Controlled Trial,” Journal of Clinical Pharmacy and Therapeutics, Vol. 35, No. 5, 2010, pp. 581-588. http://dx.doi.org/10.1111/j.1365-2710.2009.01133.x

has been cited by the following article:

• TITLE: Crocetin Prevents Amyloid β1-42-Induced Cell Death in Murine Hippocampal Cells

  AUTHORS: Yuta Yoshino, Mitsue Ishisaka, Naofumi Umigai, Masamitsu Shimazawa, Kazuhiro Tsuruma, Hideaki Hara

  KEYWORDS: Alzheimer’s Disease; Amyloid β1-42; Crocetin; HT22; Oxidative Stress

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.1, January 13, 2014

  ABSTRACT: Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ1-42. Furthermore, to clarify the mechanism underlying the protective effects of crocetin against Aβ1-42- induced cell death, we measured reactive oxygen species (ROS) production by CM-H2DCFDA kit assay. Crocetin at 1 -10 μM protected HT22 cells against Aβ1-42-induced neuronal cell death and decreased ROS production increased by Aβ1-42. These results that crocetin has the potent neuroprotective effect against Aβ1-42-induced cytotoxicity in hippocampal cells by attenuating oxidative stress, suggest that crocetin may provide a useful therapeutic strategy against Aβ-related disorders.