TITLE:
Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review
AUTHORS:
José Martínez Reyes, Lenin Ejecatl Medina Orozco, Melitón Estrada Jaramillo, Iván Vera Romero, Agustina Ortiz Soriano
KEYWORDS:
DNA; Chemical; Degradation
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.1,
January
10,
2014
ABSTRACT: Deoxyribonucleic acid (DNA)
or oligonucleotides, can be modified in several ways as chemical
degradation by electrophilic reaction, attack of radicals, hydrolytic deamination or oxidative damage
caused by ionizing radiation. This work discussed these degradation mechanisms,
determining the effects on these biomolecules. The actual knowledge about DNA
damages only permits partial enzymatic repair treatments.