TITLE:
The Adenosine Receptor Agonist 5’-N-Ethylcarboxamide-Adenosine Increases Glucose 6-Phosphatase Expression and Gluconeogenesis
AUTHORS:
Koichi Matsuda, Yoko Horikawa, Yasuto Sasaki, Shigeko F. Sakata
KEYWORDS:
5’-N-Ethylcarboxamide-Adenosine; Glucose 6-Phosphatase; Gluconeogenesis
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.1,
January
8,
2014
ABSTRACT: Intraperitoneal administration of the
non-selective adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine
(NECA) (0.1 or 0.3 mg/kg) increased fasting serum glucose levels in mice. To
clarify the mechanism responsible for this, the expression of liver glucose
6-phosphatase (G6Pase: a gluconeogenic enzyme) was analyzed, and it was found
that G6Pase mRNA was increased by NECA treatment. Administration of 0.3 mg/kg
NECA resulted in elevated serum glucose levels at 1 h and were further elevated
at 6 h. Administration of 0.1 mg/kg NECA increased serum glucose levels at 1 h
and had returned to control levels by 6 h. The increase in fasting serum glucose
levels induced by NECA are thought to be caused, in part, by elevated G6Pase
expression.