TITLE:
Histologic Types of Chest Wall Tumors—Nine Years’ Single Center Experience
AUTHORS:
Zohreh Mohammadtaheri, Atosa Dorudinia, Abolghasem Daneshvar, Pegah Akhavan Azar, Foruzan Mohammadi
KEYWORDS:
Chest Wall; Histology; Immunohistochemistry; Primary; Metastatic Tumor
JOURNAL NAME:
Open Journal of Pathology,
Vol.4 No.1,
January
8,
2014
ABSTRACT: Background:
Chest wall tumors are rare and mostly malignant. More than half of the
malignancies are primary and the remainder are metastatic. Many studies have
reported that metastatic lesions occur with about the same frequency as primary
tumor. We evaluate common histological types of chest wall tumors in a tertiary
center for respiratory and thoracic diseases (National Research Institute of Tuberculosis
and Lung Disease). Method: We performed a retrospective study of chest wall
tumors at National Research Institute of Tuberculosis and Lung Disease (NRITLD)
from April 2001 to March 2010. The pathology slides of patients were retrieved
from the pathology archive of NRITLD and reviewed by two pathologists. The
lesions were classified as primary or metastatic according to the relevant
clinical data and imaging findings. Result: A total of 124 chest wall tumors
were identified in patients with a mean age of 47.7 years (range 4-90 years).
The male/female ratio was 2:1. The most commonly affected side was the right
(42.7%). There were 105 malignant tumors (84.7%), out of which 49 (46.2%) were
primary and 57 (53.8%) were metastatic in origin. The majority of the
metastatic lesions were epithelial tumors (36/57) (63.1%). The metastatic
origin was clear in 51 cases, mostly arising from the lungs (35.7%). The most
common types of primary chest wall tumors were primitive neuroectodermal tumor
(15/49, 30.6%), chondrosarcoma (7/49, 14.3%), and malignant fibrous
histiocytoma, undifferentiated pleomorphic sarcoma (5/49, 10.2%). The most
common benign tumor was lipoma (5/18, 35.7%). Conclusion: Most common tumors of chest wall in this study were
malignant, mostly metastatic epithelial neoplasms.