TITLE:
Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction
AUTHORS:
Eduard Dotsenko, Dmitry Salivonchyk, Osain Menizibeya Welcome, Konstantin Dotsenko, Sergei Salivonchyk, Valery Bobkov, Natalia Nikulina, Eugenia Semeniago, Svetlana Nerobeeva
KEYWORDS:
Hyperbaric Oxygenation Treatment; Myocardial Infarction; Recurrent Myocardial Infarction; Clinical Outcomes; Mortality Rate; Survival Rate
JOURNAL NAME:
Health,
Vol.6 No.1,
January
7,
2014
ABSTRACT: Surgical treatments of acute myocardial infarction
(MI) possess a high clinical effectiveness, but there are fixed limitations,
related to the patient’s state, which are limited by medical resources and
organizational problems. The development of
new medical technologies provides a better and effective non-surgical
treatment of acute MI and increases long-term prognosis in this category of
patients. The study aims to investigate the influence of hyperbaric oxygenation
treatment on clinical outcomes (survival rate and recurrent myocardial
infarction (rMI)) during the five-year period of monitoring. The study involved
697 patients who suffered from acute MI, having undergone the standard treatment.
The patients were randomly divided into two groups: Group 1 (reference, n = 363);
Group 2 (test, n = 334). Patients of Group 2 were given the traditional
treatment, accompanied with HBOT (isopression for forty minutes at a working
pressure of 0.03 MPa). HBOT was applied first through the fifth day following
MI. The treatment course included six cycles, once per day. The clinical
assessment was focused on clinical outcome: rMI and mortality related to
cardiovascular events. HBOT application that accompanied the acute MI with
traditional pharmacotherapy has been proved to reduce rMI within five years
following inpatient discharge (rMI rate was
14% in the reference group and 5.4% in the test group, χ2 = 13.3, р