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Kaufman, R.H., Adam, E., Hatch, E.E., Noller, K., Herbst, A.L., Palmer, J.R., et al. (2000) Continued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspring. Obstetrics & Gynecology, 96, 483-489.

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• TITLE: Midtrimester pregnancy loss and cervical incompetence—Is there an association with connective tissue laxity?

  AUTHORS: Shirley Au, Fiona Cullinane, Ravi Savarirayan, Sonia R. Grover

  KEYWORDS: Cervical Incompetence; Connective Tissue Laxity; Ehlers Danlos Syndrome; Pregnancy Complications; Beighton Score

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.4 No.1, January 6, 2014

  ABSTRACT: Objectives: The basic mechanisms of cervical incompetence remain unknown although preliminary histological, biochemical and DNA studies suggest connective tissue pathology may be a contributing factor. Certain connective tissue disorders are known to be associated with obstetric complications. Utilising a standardised established scoring system for connective tissue laxity, this study aimed to test the relationship between clinical evidence of connective tissue laxity and cervical incompetence. Methods: This case-control study involved pregnant and non-pregnant women with a history of mid-trimester pregnancy loss in the absence of major bleeding, infection and uterine abnormalities and a control group of women with uncomplicated obstetric histories. Relevant medical details were obtained. Connective tissue laxity was assessed utilizing the Beighton scoring system. Potential confounding factors, including age, pregnancy and gestation were explored. Results: The frequency of connective tissue laxity between the cases [n = 29] was not statistically different from the controls [n = 58] [p = 0.391] suggesting a lack of association between cervical incompetence and clinical evidence of connective tissue laxity. Conclusion: Although no clear evidence of connective tissue laxity was demonstrated, it is possible that cervical incompetence is associated with abnormal connective tissue. But this abnormality is different from the defect that underlies joint hypermobility and skin elasticity.