TITLE:
Formulation of a new phenytoin-containing mucoadhesive and evaluation of its healing effects on oral biopsy ulcers
AUTHORS:
Maryam Baharvand, Ardeshir Lafzi, Ahmad R-Mafi, Jamileh-Bigom Taheri, Hamed Mortazavi, Somayeh Alirezaei
KEYWORDS:
Mucoadhesive Paste; Phenytoin; Oral Ulcer
JOURNAL NAME:
Open Journal of Stomatology,
Vol.4 No.1,
January
3,
2014
ABSTRACT: Background and Objective: Several studies have shown
the wound healing effect of topical phenytoin, which is applied by its effect on
connective tissue intracellular matrix. However, there are still some controversies
about its effect on various kinds of wounds, especially in the experimental
models. This study is aimed at evaluating the effect of mucoadhesive paste compared to phenytoin mucoadhesive paste on wound healing after oral biopsy. Material and Methods: In this double blind randomized clinical trial, 20 patients who were
eligible for oral biopsy were allocated into the case and control groups. After
the biopsy, patients having ulcers ranging between one and two centimeters
were treated by simple or 1% phenytoin mucoadhesive paste. All patients were
instructed to apply their paste at least three times a day for five days after
the biopsy. Patients in both groups were evaluated every other day for size of
the ulcer, degree of pain and diameter of the inflammatory halo. Statistical
analysis was done using SPSS software and Mann-Whitney test. Results: After
the second and third appointments, it was observed that the rate of wound
healing and decrease in the size of the ulcers were significantly quicker in
the treatment group (p = 0.001 and p = 0.003 respectively) and the patients
in the phenytoin group reported less pain. Diameter of the inflammatory halo
was not significantly different between two groups. Conclusion: Applying 1% phenytoin mucoadhesive paste on biopsy ulcers resulted in accelerated wound
healing and decrease in pain, but had no effect on the diameter of the inflammatory
halo.