TITLE:
Microwave Assisted Peptide Synthesis as a New Gold Standard in Solid Phase Peptide Synthesis: Phospholamban as an Example
AUTHORS:
Shadi Abu-Baker, Philip Garber, Bryce Hina, Trevor Reed, Ghaffari Shahrokh, Mohannad Al-Saghir, Gary Lorigan
KEYWORDS:
Solid-State Peptide Synthesis; Phospholamban; Microwave Assisted Synthesis
JOURNAL NAME:
Open Journal of Synthesis Theory and Applications,
Vol.3 No.1,
December
31,
2013
ABSTRACT: In this study, we report the microwave assisted synthesis of Phospholamban protein (WT-PLB) as a new gold standard in solid phase peptide synthesis. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis. The use of microwave energy for both the coupling and deprotection steps makes the microwave peptide synthesizers the most versatile and powerful systems available. It produces high yield and fast synthesis when compared to conventional peptide synthesizers.