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W. S. Jung, Y. S. Chae, D. Y. Kim, S. W. Seo, H. J. Park, G. S. Bae, T. H. Kim, H. J. Oh, K. J. Yun, R. K. Park, J. S. Kim, E. C. Kim, S. Y. Hwang, S. J. Park and H. J. Song, “Gardenia Jasminoides Protects against Cerulein-Induced Acute Pancreatitis,” World Journal of Gastroenterology, Vol. 14, No. 40, 2008, pp. 6188-6194.
http://dx.doi.org/10.3748/wjg.14.6188

has been cited by the following article:

• TITLE: Anti-Hyperglycemic Effect of Single Administered Gardeniae Fructus in Streptozotocin-Induced Diabetic Mice by Improving Insulin Resistance and Enhancing Glucose Uptake in Skeletal Muscle

  AUTHORS: Qing Yu, Tatsuo Takahashi, Masaaki Nomura, Shinjiro Kobayashi

  KEYWORDS: Gardeniae Fructus (GF); Streptozotocin (STZ); Soleus Muscle; Insulin Resistance; Glucose Uptake; Glucose Transporter 4 (GLUT4); Phosphorylation of Akt (P-Akt)

  JOURNAL NAME: Chinese Medicine, Vol.4 No.4, December 30, 2013

  ABSTRACT: The mechanisms of Gardeniae Fructus (GF) for anti-hyperglycemic action were demonstrated in streptozotocin (STZ)-diabetic mice. Six hours after single intraperitoneal administration of GF (300 mg/kg) or H2O into 3 hour-fasted STZ-diabetic mice, glucose and insulin tolerances were assessed by intraperitoneal glucose (1.5 g/kg) tolerance test (IPGTT) and intraperitoneal insulin (0.65 U/kg) tolerance test (IPITT), respectively. Effects of GF on insulin signaling pathways in soleus muscle such as glucose uptake, expression of glucose transporter 4 (GLUT4) in the plasma membrane and phosphorylation of Akt (P-Akt) in cytosolic fraction were examined in STZ-diabetic mice. In IPGTT test, GF significantly accelerated clearance of exogenous glucose and its glucose-lowering action was greater than H2O-treated controlin STZ-diabetic mice. GF also promoted an exogenous glucose-increased insulin level in STZ-diabetic mice. In IPITT test, GF decreased glucose level to the greater extent than H2O-treated control in STZ-diabetic mice. Furthermore, GF significantly decreased high HOMA-IR in STZ-diabetic mice from 21.6 ± 2.4 to 12.4 ± 1.9 (mg/dl × μU/ml). These results implied that GF improved insulin resistance in STZ-diabetic mice. GF increased glucose uptake of soleus muscle 1.5 times greater than H2O-treated control in STZ-diabetic mice. GF enlarged insulin (10 nmol/ml)-increased glucose uptake to 1.8 time-greater. Correspondingly, GF increased expression of GLUT4 in the plasma membrane of soleus muscle to 1.4 time-greater, and P-Akt in the cytosolic fraction of soleus muscle to 1.9 time-greater than those in H2O-treated control. In conclusion, the improvement of GF on insulin resistance is associated with the repair of insulin signaling via P-Akt, GLUT4 and glucose uptake pathway in soleus muscle of STZ-diabetic mice.