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Spieth, P.M., Carvalho, A.R., Pelosi, P., Hoehn, C., Meissner C., Kasper, M., Hubler, M., von Neindorff, M., Dassow, C., Barrenschee, M., Uhlig, S., Koch, T. and de Abreu, M.G. (2009) Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. American Journal of Respiratory and Critical Care Medicine, 179, 684-693.
http://dx.doi.org/10.1164/rccm.200806-975OC

has been cited by the following article:

• TITLE: Modeling the effects of stretch-dependent surfactant secretion on lung recruitment during variable ventilation

  AUTHORS: Samir D. Amin, Arnab Majumdar, Phil Alkana, Allan J. Walkey, George T. O’Connor, Béla Suki

  KEYWORDS: Computational Modeling; Mechanical Ventilation; Variable Ventilation; Surfactant Secretion Dynamics

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.12A, December 27, 2013

  ABSTRACT: Variable ventilation (VV) is a novel strategy of ventilatory support that utilizes random variations in the delivered tidal volume (VT) to improve lung function. Since the stretch pattern during VV has been shown to increase surfactant release both in animals and cell culture, we hypothesized that there were combinations of PEEP and VT during VV that led to improved alveolar recruitment compared to conventional mechanical ventilation (CV). To test this hypothesis, we developed a computational model of stretch-induced surfactant release combined with abnormal alveolar mechanics of the injured lung under mechanical ventilation. We modeled the lung as a set of distinct acini with independent surfactant secretion and thus pressure-volume relationships. The rate of surfactant secretion was modulated by the stretch magnitude that an alveolus experienced per breath. Mechanical ventilation was simulated by delivering a prescribed VT at each breath. The fractional VT that each acinus received depended on its local compliance relative to the total system compliance. Regional variability in VT thus developed through feedback between stretch and surfactant release and coupling of regional VT to ventilator settings. The model allowed us to simulate patient-ventilator interactions over a wide range of PEEPs and VTs during CV and VV. Full recruitment was achieved through VV at a lower PEEP than required for CV. During VV, the acini were maintained under non-equilibrium steady-state conditions with breath-by-breath fluctuations of regional VT. In CV, alveolar injury was prevented with high-PEEP-low-VT or low-PEEP-high-VT combinations. In contrast, one contiguous region of PEEP-VT combinations allowed for full recruitment without overdistention during VV. We found that maintaining epithelial cell stretch above a critical threshold with either PEEP or VT may help stabilize the injured lung. These results demonstrate the significance of patient-ventilator coupling through the influence of cellular stretch-induced surfactant release on the whole lung stability.