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has been cited by the following article:

• TITLE: Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer

  AUTHORS: Shinichi Yamauchi, Satoru Iida, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetake, Kenichi Sugihara

  KEYWORDS: Platelet-Derived Growth Factor-C; Colorectal Cancer; Prognosis, mRNA Expression; Immunohistochemistry

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.1, December 27, 2013

  ABSTRACT: Platelet-derived growth factors (PDGFs) are known to be associated with tumor growth and angiogenesis through their activation of the receptor tyrosine kinases, PDGF receptors alpha and beta. Several studies revealed the participation of the PDGF family in colorectal cancer (CRC). However, the role of platelet derived growth factor-C (PDGFC) in CRC is less well studied. This study aimed to determine the correlation between PDGFC expression and the prognosis of patients with CRCs. Tumor samples were obtained from patients with CRC who underwent surgical resection between 2002 and 2006. The mRNA expression of PDGFC was investigated by quantitative reverse transcription-polymerase chain reaction in 85 patients with stage I-IV CRC. PDGFC protein expression was analyzed by immunohistochemistry, and the relationship between PDGFC protein expression and clinicopathologic features was investigated in 245 patients with stage I-III CRC. PDGFC mRNA expression in cancer tissues was significantly higher in patients with distant metastases than in those without metastases (P = 0.016). PDGFC protein overexpression was associated with significantly worse overall and relapse-free survival (P P - 6.081, P