TITLE:
New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl
AUTHORS:
Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur D. Khunt, V. V. N. K. V. Prasada Raju, Bojja Ramachandra Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy
KEYWORDS:
Valacyclovir Hydrochloride; Antiviral Drug; N-Phthalimide-L-Valine Ester; Monomethylamine; Commercially Scalable Process; Less Cycle Time
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.3 No.4,
December
27,
2013
ABSTRACT: This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.