Article citationsMore>>

J. Soul-Lawton, E. Seaber, N. On, R. Wootton, P. Rolan and J. Posner, “Absolute Bioavailability and Metabolic Disposition of Valacyclovir, the L-valyl Ester of Acyclovir, Following Oral Administration to Humans,” Antimicrobial Agents and Chemotherapy, Vol. 39, No. 12, 1995, p. 2759.

has been cited by the following article:

• TITLE: New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl

  AUTHORS: Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur D. Khunt, V. V. N. K. V. Prasada Raju, Bojja Ramachandra Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy

  KEYWORDS: Valacyclovir Hydrochloride; Antiviral Drug; N-Phthalimide-L-Valine Ester; Monomethylamine; Commercially Scalable Process; Less Cycle Time

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.4, December 27, 2013

  ABSTRACT: This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.