Article citationsMore>>

T. A. Fairley, R. R. Tidwell, I. Donkor, N. A. Naiman, K. A. Ohemeng, R. J. Lombardy, J. A. Bentley and M. Cory, “Structure, DNA Minor Groove Binding, and Base Pair Specificity of Alkyland Aryl-Linked Bis(amidinobenzimidazoles) and Bis(amidinoindoles),” Journal of Medicinal Chemistry, Vol. 36, No. 12, 1993, pp. 1746-1753.
http://dx.doi.org/10.1021/jm00064a008

has been cited by the following article:

• TITLE: Synthesis of Multifunctionalised 2-Substituted Benzimidazoles Using Copper (II) Hydroxide as Efficient Solid Catalyst

  AUTHORS: Murugulla Adharvana Chari, Zaied-A-Mosaa, Donthabakthuni Shobha, Sridhar Malayalama

  KEYWORDS: o-Phenylenediamine; Aldehydes; Copper (II) Hydroxide; Solid Catalyst; Multifunctionalised Benzimidazoles

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.4, December 27, 2013

  ABSTRACT: Here we demonstrate the synthesis of multifunctionalised benzimidazoles through the coupling of o-phenylenediamine with aldehydes by using Copper (II) hydroxide as an efficient solid catalyst in methanol at room temperature. The Copper (II) hydroxide solid catalyst gave better yields (80%-99%) in short reaction time (4-8 h). These commercially available cheap catalysts are more active than many reported expensive heterogeneous catalysts. Using the Copper hydroxide fresh catalyst, the yield of product 3a was 98%, while the recovered catalyst in the three subsequent cycles gave the yield of 94%, 90% and 88% respectively.