TITLE:
Viral Characteristic of HIV Infected Patients Naïf of Anti-Retroviral Therapy with CD4+ T Lymphocytes Rate Greater than 350 per Microliter of Blood in Lomé Togo
AUTHORS:
Ihou Nazoba Majesté Wateba, Akouda Akessiwe Patassi, Abago Balaka, Ousséni Tidjani
KEYWORDS:
Viral Load; CD4+ T Lymphocytes; Naive Anti-Retroviral Therapy Patients
JOURNAL NAME:
World Journal of AIDS,
Vol.3 No.4,
December
27,
2013
ABSTRACT: Objective: To evaluate
the virological status of ineligible HIV patients for anti-retroviral therapy based on the criterion of CD4+ T lymphocytes rate over
than 350/μl of blood. Method: This is a prospective study which was
conducted from November 2011 to July 2012 in the tropical and infectious
disease department of CHU Sylvanus Olympio of Lomé. All HIV-1 infected patients
whose CD4+ T lymphocytes rate was ≥350/μl of blood were retained. The count of CD4+
T lymphocytes was made by cytometer FACSCalibur? flow of BD biosciences
and the determination of viral load was achieved by NASBA laboratory method of
Biomérieux. Results: We have
recruited 102 PLWHA aged between 19 and 58 years with a median of 35 years.
Biologically, 102 patients had a T-CD4 rate between 355 and 432/μl of blood.
The determination of viral load showed a very high viral replication more than
10,000 copies/ml
among all patients and 28 (27.5%) patients had a viral load > 100,000 copies/ml of blood. Conclusion: Our results argue for a reconsideration of the criteria for
starting antiretroviral therapy in Togo by including virological data if
necessary in patients with T-CD4 rate below 500/μl of blood.