TITLE:
In Vitro Preliminary Evidences on the Antioxidant Properties of Biogenic Amines
AUTHORS:
Roberto Stevanato, Mariangela Bertelle, Sabrina Fabris
KEYWORDS:
Biogenic Amines; Antioxidants; Lipid Peroxidation; DNA Protection; Membrane Protection
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.4 No.9,
December
26,
2013
ABSTRACT: Antioxidant properties of the
principal biogenic amines were determined in
vitro by four analytical
methods—Folin Ciocalteu, DPPH, enzymatic and
inhibition of lipid peroxidation—in order to avoid possible measuring-method linked
mistakes. Different
results are obtained, depending on the parameters that each of them measures. The combination of the data indicates that all examined amines show antioxidant characteristics: in particular, tyramine,
serotonin, L-norepinephrine, (-)-epinephrine and dopamine owing to their
(poly)phenolic structure too, while aliphatic polyamines-spermine, spermidine,
putrescine and cadaverine-histamine, melatonin and
tryptamine appear to act specifically on the oxygen-consuming species involved
in the lipid peroxidation of polyunsaturated fatty acids.